San Francisco 49ers at Buffalo Bills odds, picks and predictions

The San Francisco 49ers (5-6) try to salvage their season against the Buffalo Bills (9-2) on Sunday Night Football. Kickoff from Highmark Stadium is set for 8:20 p.m. ET (NBC). Let’s analyze BetMGM Sportsbook’s NFL odds around the 49ers vs. Bills odds, and make our expert NFL picks and predictions.

The Niners’ season is on life support in the basement of the NFC West. The good news is they’re just 1 win under the division-leading Seattle Seahawks. The bad news is they have to leapfrog 3 teams to take the West crown. The 49ers have lost 2 straight after a 38-10 defeat in the Frozen Tundra of Green Bay last week. QB Brandon Allen threw for 199 yards, 1 TD and 1 INT. QB Brock Purdy (shoulder) is expected back for this one.

The Bills exit their bye week after outclassing the Kansas City Chiefs 30-21. QB Josh Allen went 27-for-40 for 262 yards, 1 TD and 1 INT, but his 26-yard rushing touchdown was the eventual game-winner. RB James Cook amassed just 20 yards on 9 carries, but 2 of those ended in the end zone. Buffalo has won 6 straight.

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49ers at Bills odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list of NFL odds. Lines last updated Saturday at 2:40 p.m. ET.

Moneyline (ML): 49ers +225 (bet $100 to win $225) | Bills -275 (bet $275 to win $100)
Against the spread (ATS): 49ers +6 (-110) | Bills -6 (-105)
Over/Under (O/U): 44.5 (O: -110 | U: -110)

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49ers at Bills key injuries

49ers

DE Nick Bosa (hip, oblique) out
CB Deommodore Lenoir (knee) out
QB Brock Purdy (shoulder) probable
OT Trent Williams (knee) out

Bills

WR Keon Coleman (wrist) questionable
TE Dalton Kincaid (knee) out
LB Matt Milano (biceps) questionable

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49ers at Bills picks and predictions

Prediction

49ers 20, Bills 17

Moneyline

This game is going to be ugly in the best kind of way. Heavy snowfall is expected with strong winds and a gametime temperature of 27 degrees. The Bills have run away with the AFC East, and this one means so much more to San Francisco than Allen and Co. The absence of Kincaid, who is great on underneath and short-yardage routes is also key.

Yes, the Niners are a warm-weather team. Purdy played 4 years at Iowa State, which is susceptible to cold temps. Purdy, RB Christian McCaffrey and TE George Kittle can’t be counted out here. In a battle of fortitude, the Niners need it more. I’m taking my shot on 49ERS +225.

Against the spread

If you aren’t completely on board with my bold prediction, I still think 49ERS +6 (-110) is a good bet. The conditions will keep the ball out of the air for the most part. San Francisco’s backs, particularly Jordan Mason, match up well with Buffalo’s.

Over/Under

This is an Under game. With the forecast, I’m really surprised the total hasn’t slipped below 40. Heavy snow, cold temps and wind make for an UNDER 44.5 (-110) cash.

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