It’s been a brutal year for injuries in the NFL, and the Bills have not been safe from the carnage. A couple reports today provided some insight on some of the team’s short-term and long-term injury situations. 
In the short term, a report from earlier this week that pass rusher Joey Bosa would miss some time was confirmed with the release of the team’s final injury report of the week. As the defensive end missed the entire week of practice with a hamstring injury, he’s been ruled out for this weekend. The same is true of linebacker Terrel Bernard, who missed last week, as well, with an elbow injury.
In Bernard’s absence last week, veteran linebacker Shaq Thompson stepped up as a replacement starter. Injuries have made Buffalo extremely thin at defensive end, though. With Bosa out, A.J. Epenesa should see an increased role across from Gregory Rousseau. At times this year, second-year pass rusher Javon Solomon has seen some increased usage, and this could be a perfect opportunity to earn more playing time. The team has also shifted defensive tackle T.J. Sanders out to the edge recently to fill out the line.
In the long term, Joe Buscaglia of The Athletic offers a glimmer of hope for defensive tackle Ed Oliver. A long-time pillar on the defensive line in Buffalo, Oliver has been out since the third week of the season with a torn bicep. At the time of the injury, there was some speculation that he may be able to make a return in time for the playoffs, and head coach Sean McDermott has maintained that a window could exist in which Oliver would have the potential to return after the regular season but in time for the playoffs. Anything sooner, though, is not considered likely.
Additionally, any hope of reinforcement from third-round rookie pass rusher Landon Jackson has been shut down. The prolific pass rushing Razorback saw his rookie season put on pause when he suffered a torn MCL and PCL in November. Per Buscaglia, McDermott confirmed today that Jackson is not returning this year.